Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway

Figure 5

Inhibition of p38 reverses the SAA mediated RASMC phenotype switch. RASMCs were pretreated with the p38 inhibitor SB203580 (50 μM) for 30 min followed by SAA treatment. (a) Western blots analysis of phosphorylated and total p38 protein expression. (b) qPCR analysis of the effect of the p38 inhibitor on SAA-induced RASMC phenotype modulation. (c) Western blot analysis of the effect of the p38 inhibitor on SAA-induced RASMC phenotype modulation and the phosphorylated and total ERK1/2. , versus SAA-treated group. Data shown are means ± SD from three independent experiments.

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