Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide

Figure 4

The effect of ferulic acid on mRNA levels of APP (a), BACE1 (b), PS1 (c), PS2 (d), ADAM10 (e), NEP (f), and ECE1 (g) in H₂O₂-stimulated HLE cells. The 10 μM H₂O₂ and 0–30 μM ferulic acid were added simultaneously to the medium, and the HLE cells were incubated for 24 h. Open columns = H₂O₂-stimulated HLE cells. Closed columns = H₂O₂-stimulated HLE cells with ferulic acid treatment. The data are presented as the means ± SE of 5–8 experiments. , versus H₂O₂-stimulated HLE cells in the absence of ferulic acid (open columns) for each category.

(a) APP mRNA

(b) BACE1 mRNA

(c) PS1 mRNA

(d) PS2 mRNA

(e) ADAM10 mRNA

(f) NEP mRNA

(g) ECE1 mRNA