Research Article
Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide
Figure 5
The effect of 0.1 μM of ferulic acid on the production of Aβ1–40 (a), Aβ1–42 (b), Aβ1–43 (c) levels, and mRNA levels of APP (d), BACE1 (e), PS1 (f), PS2 (g), ADAM10 (h), NEP (i), and ECE1 (j) in HLE cells. The 0.1 μM of ferulic acid was added simultaneously to the medium, and the HLE cells were incubated for 24 h. Open columns = the naïve HLE cells. Closed columns = HLE cells in the presence of 0.1 μM ferulic acid. N.D. = not detectable. The data are presented as the means ± SE of five experiments. , versus naïve HLE cells (open columns) for each category.
| (a) Aβ1–40 levels |
| (b) Aβ1–42 levels |
| (c) Aβ1–43 levels |
| (d) APP mRNA |
| (e) BACE1 mRNA |
| (f) PS1 mRNA |
| (g) PS2 mRNA |
| (h) ADAM10 mRNA |
| (i) NEP mRNA |
| (j) ECE1 mRNA |