CD36 Gene Polymorphisms Are Associated with Intracerebral Hemorrhage Susceptibility in a Han Chinese Population
Table 3
Comparison of the genotype and allele frequencies of associated CD36 gene variants between ICH patients and controls.
SNPs
Genotype
Frequency
Additive model
Dominant model
Recessive model
Allele
Frequency
Multiplicative model
ICH patients, 292(%)
Control patients, 298(%)
OR (95% CI)
P
OR (95% CI)
OR (95% CI)
ICH patients, (%)
Control patients, (%)
OR (95% CI)
rs1049654
AA
135 (46.2)
115 (38.6)
0.112
0.798 (0.604–1.054)
0.069
0.698 (0.474–1.028)
0.569
0.849 (0.484–1.49)
A
394 (67.5)
373 (62.6)
0.079
1.24 (0.975–1.576)
AC
124 (42.5)
143 (48.0)
C
190 (32.5)
223 (37.4)
CC
33 (11.3)
40 (13.4)
rs1049673
CC
60 (20.5)
63 (21.2)
0.847
1.027 (0.783–1.346)
0.894
0.972 (0.638–1.48)
0.632
1.121 (0.703–1.787)
C
265 (45.4)
276 (46.3)
0.748
0.963 (0.766–1.211)
CG
145 (49.7)
150 (50.3)
G
319 (54.6)
320 (53.7)
GG
87 (29.8)
85 (28.5)
rs1194182
GG
137 (46.9)
118 (39.6)
0.072
0.772 (0.583–1.024)
0.046
0.674 (0.457–0.992)
0.481
0.814 (0.459–1.445)
G
398 (68.2)
378 (63.4)
0.087
0.81 (0.637–1.031)
GC
124 (42.5)
142 (47.7)
C
186 (31.8)
218 (36.6)
CC
31 (10.6)
38 (12.7)
rs12666644
GG
258 (88.3)
245 (82.2)
0.208
0.723 (0.436–1.198)
0.131
0.664 (0.39–1.13)
0.381
3.211 (0.237–43.56)
G
548 (93.8)
542 (90.9)
0.979
1.517 (0.979–2.35)
GA
32 (11.0)
52 (17.5)
A
36 (6.2)
54 (9.1)
AA
2 (0.7)
1 (0.3)
rs12706949
GG
83 (28.4)
88 (29.5)
0.787
0.963 (0.734–1.264)
0.509
0.868 (0.57–1.322)
0.786
1.067 (0.667–1.707)
G
315 (53.9)
323 (54.2)
0.93
0.99 (0.787–1.244)
GT
149 (51.0)
147 (49.3)
T
269 (46.1)
273 (45.8)
TT
60 (20.6)
63 (21.2)
rs12706950
GG
82 (28.1)
88 (29.5)
0.788
0.963 (0.734–1.264)
0.531
0.874 (0.574–1.332)
0.814
1.058 (0.662–1.69)
G
314 (53.8)
322 (54.0)
0.929
0.99 (0.787–1.244)
GA
150 (51.4)
146 (49.0)
A
270 (46.2)
274 (46.0)
AA
60 (20.5)
64 (21.5)
rs13223096
CC
83 (28.4)
88 (29.5)
0.787
0.963 (0.734–1.264)
0.509
0.868 (0.57–1.332)
0.786
1.067 (0.667–1.707)
C
315 (53.9)
323 (54.2)
0.93
0.99 (0.787–1.244)
CT
149 (51.0)
147 (49.3)
T
269 (46.1)
273 (45.8)
TT
60 (20.6)
63 (21.2)
rs13226433
CC
59 (20.2)
62 (20.8)
0.833
1.03 (0.785–1.351)
0.869
0.965 (0.634–1.469)
0.584
1.14 (0.713–1.825)
C
264 (45.2)
275 (46.1)
0.747
0.963 (0.766–1.211)
CA
146 (50.0)
151 (50.7)
A
320 (54.8)
321 (53.9)
AA
87 (29.8)
85 (28.5)
rs13246513
CC
83 (28.4)
89 (29.9)
0.798
0.965 (0.735–1.267)
0.568
0.885 (0.528–1.346)
0.482
1.049 (0.655–1.68)
C
316 (54.1)
324 (54.4)
0.931
0.99 (0.787–1.245)
CT
150 (51.4)
146 (49.0)
T
268 (45.9)
272 (45.6)
TT
59 (20.2)
63 (21.1)
rs13344512
GG
172 (58.9)
188 (63.1)
0.11
1.302 (0.942–1.8)
0.246
1.259 (0.583–1.859)
0.09
2.203 (0.884–5.487)
G
441 (75.5)
477 (80.0)
0.062
0.769 (0.584–1.013)
GT
97 (33.2)
101 (33.9)
C
143 (24.5)
119 (20.0)
TT
23 (7.9)
9 (3.0)
rs7755
GG
60 (20.6)
63 (21.2)
0.922
1.014 (0.773–1.328)
0.78
0.942 (0.619–1.433)
0.632
1.121 (0.703–1.787)
G
264 (45.2)
276 (46.3)
0.704
0.957 (0.761–1.203)
GA
144 (49.3)
150 (50.3)
A
320 (54.8)
320 (53.7)
AA
88 (30.1)
85 (28.5)
CI, confidence interval; OR, odds ratio; SNP, single nucleotide polymorphism. Additive model: heterozygotes and minor allele homozygotes were weighed 2 and 1, respectively, to major allele homozygotes. Dominant model: major allele homozygotes versus heterozygotes plus minor allele homozygotes. Recessive model: major allele homozygotes plus heterozygotes versus minor allele homozygotes.
