Comparison of DNA Methylation in Schwann Cells before and after Peripheral Nerve Injury in Rats

Figure 5

Validation of the differential expression of 7 mRNAs of corresponding methylated genes identified in the MeDIP in ASCs compared with NSCs by qRT-PCR. Data indicate relative expression following normalization. Values are means ± SE (). (a)–(e) showed that 5 mRNAs of differentially hypermethylated genes (Dgcr8, Zeb2, Dixdc1, Sox2, and Shh) were downregulated in ASCs compared with NSCs. (f)-(g) showed that 2 mRNAs of differentially hypomethylated genes (Gpr126, Birc2) were upregulated in ASCs compared with NSCs.

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