Mechanism of Reduced Susceptibility to Fosfomycin in Escherichia coli Clinical Isolates

Table 2

Antibiotic susceptibility and the presence of ESBL genes in E.coli strains with FOM MIC ≥ 8 μg/mL.

Strains	MIC (μg/mL)					ESBLgene
	Fosfomycin; (≥128)	Levofloxacin; (≥4)	Gentamicin; (≥8)	Imipenem; (≥2)	Ceftazidime; (≥8)
SRE257	1024	≤0.125	1	0.125	0.125	—
SRE91	128	32	4	0.25	0.125	—
SRE49	128	16	2	0.125	0.25	—
SRE54	64	≥64	≥64	0.125	2	CTX-M14
SRE237	64	≤0.125	4	0.125	0.125	—
SRE29	32	16	≥64	0.125	0.125	—
SRE252	32	0.5	2	0.125	0.125	—
SRE280	32	≤0.125	8	0.5	0.125	—
SRE18	16	32	2	0.125	2	CTX-M2
SRE253	8	≤0.125	4	0.5	0.125	—

ESBL: extended spectrum β-lactamase.
Breakpoints (μg/mL) are according to CLSI.
Resistant.
Intermediate.