Association of Polymorphisms of the Receptor for Advanced Glycation Endproducts Gene with Schizophrenia in a Han Chinese Population

Table 1

Genotype and allele frequency of the RAGE gene in the patients with schizophrenia and controls.

dbSNP ID	Schizophrenia	Control	value	OR (95% CI)
	(%)	(%)
G82S
Genotype
GG	535 (58.0)	533 (61.0)
GS	336 (36.4)	296 (33.9)
SS	52 (5.6)	45 (5.1)
GS + SS	388 (42.0)	341 (39.0)		1.134 (0.939–1.369)
Allele
G	1406 (76.2)	1362 (77.9)		1.000 (reference)
S	440 (23.8)	386 (22.1)	0.212	1.104 (0.945–1.290)
-374T/A
Genotype
TT	704 (76.3)	688 (78.7)
TA	199 (21.6)	173 (19.8)
AA	20 (2.2)	13 (1.5)
TA + AA	219 (23.7)	186 (21.3)		1.151 (0.922–1.437)
Allele
T	1607 (87.1)	1549 (88.6)		1.000 (reference)
A	239 (12.9)	199 (11.4)	0.152	1.158 (0.947–1.415)
-429T/C
Genotype
TT	807 (87.4)	733 (83.9)
TC	113 (12.2)	137 (15.7)
CC	3 (0.3)	4 (0.5)
TC + CC	116 (12.6)	141 (16.1)		0.747 (0.573–0.974)
Allele
T	1727 (93.6)	1603 (91.7)		1.000 (reference)
C	119 (6.4)	145 (8.3)	0.034	0.762 (0.592–0.980)

OR: odds ratio; 95% CI: 95% confidence interval. test for the three different genotypes. were performed, GS + SS versus GG. were performed, TA + AA versus TT. were performed, TC + CC versus TT. isher’s exact test.