Association of Polymorphisms of the Receptor for Advanced Glycation Endproducts Gene with Schizophrenia in a Han Chinese Population
Table 2
Genotype and allele frequency of the RAGE gene in the patients with schizophrenia and controls, according to gender.
dbSNP ID
Male
value OR (95% CI)
Female
value OR (95% CI)
Patient
Control
Patient
Control
(%)
(%)
(%)
(%)
G82S
Genotype
GG
342 (58.3)
328 (62.1)
193 (57.4)
205 (59.2)
GS
214 (36.5)
173 (32.8)
122 (36.3)
123 (35.5)
SS
31 (5.3)
27 (5.1)
21 (6.3)
18 (5.2)
GS + SS
245 (41.7)
200 (37.9)
143 (42.6)
141 (40.8)
Allele
G
898 (76.5)
829 (78.5)
1.000 (reference)
508 (75.6)
533 (77.0)
1.000 (reference)
S
276 (23.5)
227 (21.5)
0.256 1.122 (0.920–1.370)
164 (24.4)
159 (23.0)
0.535 1.082 (0.843–1.389)
-374T/A
Genotype
TT
443 (75.5)
417 (79.0)
261 (77.7)
271 (78.3)
TA
133 (22.7)
106 (20.1)
66 (19.6)
67 (19.4)
AA
11 (1.9)
5 (0.9)
9 (2.7)
8 (2.3)
TA + AA
144 (24.5)
111 (21.0)
75 (22.3)
75 (21.7)
Allele
T
1019 (86.8)
940 (89.0)
1.000 (reference)
588 (87.5)
609 (88.0)
1.000 (reference)
A
155 (13.2)
116 (11.0)
0.109 1.233 (0.954–1.593)
84 (12.5)
83 (12.0)
0.766 1.048 (0.758–1.449)
-429T/C
Genotype
TT
516 (87.9)
441 (83.5)
291 (86.6)
292 (84.4)
TC
68 (11.6)
85 (16.1)
45 (13.4)
52 (15.0)
CC
3 (0.5)
2 (0.4)
0 (0.0)
2 (0.6)
TC + CC
71 (12.1)
87 (16.5)
45 (13.4)
54 (15.6)
Allele
T
1100 (93.7)
967 (91.6)
1.000 (reference)
627 (93.3)
636 (91.9)
1.000 (reference)
C
74 (6.3)
89 (8.4)
0.054 0.731 (0.531–1.007)
45 (6.7)
56 (8.1)
0.325 0.815 (0.542–1.225)
OR: odds ratio; 95% CI: 95% confidence interval. test for the three different genotypes. were performed, GS + SS versus GG. were performed, TA + AA versus TT. were performed, TC + CC versus TT. isher’s exact test.
