Prdx6 Upregulation by Curcumin Attenuates Ischemic Oxidative Damage via SP1 in Rats after Stroke

Figure 1

The expression of Prdx6 in the peri-infarct cortex of rats after cerebral I/R injury. (a) Real-Time PCR results show that Prdx6 mRNA levels are significantly increased 24 hours after I/R. (b) Western bolt analysis shows that Prdx6 protein levels demonstrate a significant increase after 24 h I/R. (c) Real-Time PCR results show that Prdx6 mRNA levels are inhibited by siRNA and increased by curcumin treatment. (d) Western bolt analysis shows that Prdx6 was inhibited by siRNA and increased by curcumin treatment. . versus sham group. versus I/R group.

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