c-Kit-Positive Adipose Tissue-Derived Mesenchymal Stem Cells Promote the Growth and Angiogenesis of Breast Cancer

Figure 4

The release of cytokines and chemokines in c-Kit⁺ ASCs. Cell culture supernatant and tumor tissue supernatant were collected and assayed with ELISA. ((a)–(c)) The release of IL-3 was significantly higher in the c-Kit⁺ASCs/4T1 direct coculture group in comparison with single culture; in contrast, there was a significant difference between the SDF-1 and VEGF-A levels among the groups. ((d)-(e)) The release of IL-3 as well as SDF-1 and VEGF-A was significantly increased in the coinjection group of EPCs/4T1 with c-Kit⁺ ASCs, compared with the other groups. ; .

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