Neutrophil-to-Lymphocyte Ratio Is a Potential Prognostic Biomarker in Patients with Ovarian Cancer: A Meta-Analysis

Table 2

Summary of the subgroup analysis results of NLR on PFS and OS.

Survival analysis	Included studies	Patients	HR 95% CI	p	I^2	p for heterogeneity
PFS
Cut-off value
<3.3	4	1,457	1.39 [1.03, 1.89]		53%	0.1
≥3.3	2	333	1.00 [0.23, 4.30]	1	92%	0.0004
Ethnicity
Asian	7	1,916	1.31 [0.85, 2.03]	0.22	87%	<0.00001
Therapy
Chemotherapy	3	660	1.23 [0.47, 3.24]	0.67	95%	<0.00001
Operation	4	1,256	1.29 [1.10, 1.51]		47%	0.13
OS
Cut-off value
<3.3	5	1,694	1.53 [0.99, 2.39]	0.06	67%	0.02
≥3.3	4	598	1.37 [0.51, 3.64]	0.53	88%	<0.0001
Ethnicity
Asian	9	2,138	1.76 [1.03, 3.00]		87%	<0.00001
Caucasian	2	754	1.17 [0.72, 1.90]	0.52	68%	0.08
Therapy
Chemotherapy	4	690	1.73 [0.60, 4.94]	0.31	93%	<0.00001
Operation	7	2,202	1.45 [1.02, 2.04]		68%	0.005

PFS, progression-free survival; OS, overall survival; , the difference was significant.