Research Article
Combining Carcinoembryonic Antigen and Platelet to Lymphocyte Ratio to Predict Brain Metastasis of Resected Lung Adenocarcinoma Patients
Table 2
Univariate and multivariate Cox regression analyses estimating the risk factors of brain metastases of resected lung adenocarcinoma patients.
| Clinicopathological factors | Univariable analysis | Multivariable analysis | Hazard ratio | 95% CI | value | Hazard ratio | 95% CI | value |
| Age, years | ≥60 versus <60 | 1.514 | 0.456–5.029 | 0.498 | | | | Gender | Male versus female | 0.616 | 0.199–1.910 | 0.402 | | | | Smoking status | Ever versus never | 1.230 | 0.333–4.542 | 0.756 | | | | Tumor location | Upper lobe versus nonupper lobe | 0.698 | 0.222–2.200 | 0.539 | | | | Histology grade | Well versus poor | 0.873 | 0.263–2.898 | 0.824 | | | | T stage | T3-4 versus T1-2 | 2.593 | 0.780–8.615 | 0.120 | | | | N stage | N2 versus N0-1 | 4.304 | 1.365–13.575 | 0.013 | 1.374 | 0.283–6.669 | 0.693 | TNM stage | III versus I-II | 4.976 | 1.346–18.390 | 0.016 | 2.640 | 0.440–15.829 | 0.288 | Adjuvant therapy | Yes versus no | 1.175 | 0.318–4.343 | 0.808 | | | | CEA | <5.2 ng/mL versus ≥5.2 ng/mL | 0.162 | 0.004–0.598 | 0.006 | 0.194 | 0.052–0.722 | 0.014 | Hb | ≥115 g/L versus <115 g/L | 0.510 | 0.111–2.330 | 0.358 | | | | PLR | ≥120 versus <120 | 6.085 | 1.333–27.285 | 0.020 | 5.149 | 1.117–23.729 | 0.036 |
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CI, confidence interval; CEA, carcinoembryonic antigen; Hb, hemoglobin; PLR, platelet to lymphocyte ratio.
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