Interferon-Gamma Release Assay Performance of Cerebrospinal Fluid and Peripheral Blood in Tuberculous Meningitis in China
Table 3
Diagnostic performance of routine laboratory parameters of CSF in the study population ().
Cut point#
Sensitivity
Specificity
PPV
NPV
LR+
LR−
AUC
Total WBC count, cell ×103/ml
≥46
54.7 (40.4–68.4)
70.3 (53.0–84.1)
72.5 (56.1–85.4)
52.0 (37.4–66.3)
1.84 (1.10–3.20)
0.64 (0.40–0.90)
0.67 (0.56–0.77)
CSF lymphocytes, cell ×103/ml
≥16
79.3 (65.9–89.2)
64.9 (47.5–79.8)
76.4 (63.0–86.8)
68.6 (50.7–83.1)
2.26 (1.40–3.60)
0.32 (0.20–0.60)
0.70 (0.59–0.79)
CSF ADA, U/L
≥4.7
47.2 (33.3–61.4)
94.6 (81.8–99.3)
92.6 (75.7–99.1)
55.6 (42.5–68.1)
8.73 (2.20–34.60)
0.56 (0.40–0.70)
0.68 (0.57–0.77)
CSF/serum glucose ratio
≤0.56
76.0 (61.8–86.9)
69.7 (51.3–84.4)
79.2 (65.0–89.5)
65.7 (47.8–80.9)
2.51 (1.50–4.30)
0.34 (0.20–0.60)
0.75 (0.64–0.83)
CSF glucose, mmol/L
≤2.8
81.1 (68.0–90.6)
73.0 (55.9–86.2)
81.1 (68.0–90.6)
73.0 (55.9–86.2)
3.00 (1.70–5.20)
0.26 (0.10–0.50)
0.77 (0.67–0.85)
CSF protein level, g/L
≥0.6
83.0 (70.2–91.9)
67.6 (52.2–82.0)
78.6 (65.6–88.4)
73.5 (55.3–87.3)
2.56 (1.60–4.10)
0.25 (0.10–0.50)
0.72 (0.61–0.81)
CSF chloride concentration, mmol/L
≤117.7
52.8 (38.6–66.7)
83.8 (68.0–93.8)
82.4 (65.5–93.2)
55.4 (41.5–68.7)
3.26 (1.50–7.10)
0.56 (0.40–0.80)
0.68 (0.58–0.78)
CSF, cerebrospinal fluid; ADA, adenosine deaminase; WBC, white blood cell; PPV, positive predictive value; NPV, negative predictive value; LR+, positive likelihood ratio; LR−, negative likelihood ratio; AUC, area under ROC curve. # The cut-off of the parameters was established by a new ROC curve between TBM and non-TBM group.
