Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications
Table 1
The effects of ethanol and phospholipids content of ethosome formulations on physical appearance, vesicle size, pdI, zeta potential, and PR entrapment efficiency.
Composition
Physical property
Vesicle size (nm)
pdI
Zeta potential (mV)
Entrapment efficiency (%)
SPC
CHOL
Ethanol
Water
(% w/v)
(% v/v)
3
0.5
10
90
Crystals were observed
ND
ND
ND
20
80
Yellow colloidal
30
70
Yellow colloidal
388.8 ± 8.0
0.266 ± 0.021
−34.19 ± 0.44
71.43 ± 0.77
40
60
Yellow colloidal
50
50
Crystals were observed at 1 week
60
40
Yellow colloidal precipitate
ND
ND
ND
6
0.5
10
90
Yellow colloidal
20
80
Yellow colloidal
30
70
Yellow colloidal
40
60
Yellow colloidal
50
50
Yellow colloidal
60
40
Yellow colloidal precipitate
ND
ND
ND
Each data represents the mean ± SD (n = 3). ND: not detected.
