SHISA3 Promoter Methylation Is a Potential Diagnostic and Prognostic Biomarker for Laryngeal Squamous Cell Carcinoma

Table 2

Association between the SHISA3 methylation in LSCC and the clinicopathological features. N: number; M: methylation; U: unmethylation; value calculated by Fisher’s exact test.

Characteristics	SHISA3 methylation
	N	M	U		P
Gender
Female	4	3	1	—	1^#
Male	89	63	26
Age
60	49	36	13	0.31	0.57
60	44	30	14
Smoking behavior
Yes	75	53	21	0.08	0.78
No	18	13	6
Histological grade
Well/moderately	80	53	27	—	0.02^#
Poorly	13	13	0
Clinical stage
I + II	48	29	19	5.36	0.02
III + IV	45	37	8
Tumor invasion
1 + 2	58	37	21	3.85	0.05
3 + 4	35	29	6
Lymph node metastasis
No	64	41	23	4.75	0.03
Yes	29	25	4