SHISA3 Promoter Methylation Is a Potential Diagnostic and Prognostic Biomarker for Laryngeal Squamous Cell Carcinoma

Table 3

Multivariate Cox proportional hazards analysis in 93 LSCC patients. N: number; Ref: reference category; HR: hazard ratio; CI: confidence interval.

Characteristics	N	P value	HR	95% CI
Age	93	0.979	0.999	0.953–1.048
Smoking behavior
No (Ref)	18	—	1	—
Yes	75	0.288	0.636	0.276–1.465
Differentiation
Well (Ref)	45	—	1	—
Moderated	35	0.256	0.656	0.318–1.356
Poorly	13	0.24	0.512	0.167–1.566
Clinical stage
Stage I (Ref)	29	—	1	—
Stage II	19	0.783	1.196	0.336–4.257
Stage III	12	0.053	3.735	0.982–14.208
Stage IV	33	0.019	4.238	1.272–14.117
Lymphatic metastasis
No (Ref)	64	—	1	—
Yes	29	0.723	1.172	0.489–2.809
Methylation
No (Ref)	27	—	1	—
Yes	66	0.045	2.71	1.024–7.177