Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases

Table 1

The function of miR-17-92 cluster and the relationship with cardiovascular disease.

Cardiac; parameter	Effects of miR-17-92	Target	Reference
Cardiomyocyte differentiation	Interference cardiac morphogenesis; Promote differentiation	T-box; Isl1	[25]
Cardiomyocyte proliferation	MiR-19 promotes cardiomyocyte growth and proliferation	Wnt signaling pathway	[21]
	Support proliferation of endothelial cells of cardiac blood vessels	MAPK, Elk-1	[27]
MI	Upregulate proliferation of cardiomyocytes, improve cardiac function, and reduce scar size		[21]
	MiR-19 protects ischemic injury	PTEN	[13]
	MiR-92a restrains endothelial cell angiogenesis	MKK4, KLF4	[29]
IRI	Resistance to apoptosis	MAPK/ERK, PI3K/AKT signaling pathway	[36]
	MiR-19b alleviate apoptosis and improve survival of H9C2 cardiomyocyte	PTEN	[37]
Aging	Inhibit aging process	Cdc42-SRF signaling pathway	[38]
	Prevent cardiac fibroblast senescence	Par4-CEBPB-FAK signaling pathway	[39]