miR-503 Is Involved in the Protective Effect of Phase II Enzyme Inducer (CPDT) in Diabetic Cardiomyopathy via Nrf2/ARE Signaling Pathway

Figure 4

The Nrf2 was the target gene of miR-503; (a) putative miR-503 binding sequence in the wnt3a 3′-UTR and the site-directed mutant Nrf2 3′-UTR. (b, c) The WT or mut reporter plasmids or NC- mimics (empty vector) or rno-miR-503 mimics (stable miR-503-overexpressing) were cotransfected into HEK293T cells. Relative repression of firefly luciferase expression was standardized to a transfection control. .

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