The Anti-Inflammatory Activity of Toonaciliatin K against Adjuvant Arthritis

Figure 3

The antiedema effect of toonaciliatin K in carrageenan-induced paw edema SD rats. Rats were pretreated with toonaciliatin K (8.3, 16.5, or 33 mg/kg, iv) for 4 h. The DEX (5 mg/kg, p.o) was administrated for 24 h as positive group. The same volume of 5% DMSO/saline was injected into vehicle. (a) Effect of toonaciliatin K pretreatment on carrageenan-induced rats paw edema. Furthermore, the antiadjuvant arthritis effect of toonaciliatin K in rats was tested. Toonaciliatin K was injected using tail vein at the dosage of 8.3, 16.5, or 33 mg/kg each three days in total of 27 days of administration. The same volume 5% DMSO/saline was injected into vehicle. The IND (20 mg/kg) was administered orally once a day as positive. There was no intervention to control group. (b) The paw swelling increased in each group after toonaciliatin K administration. (c) The arthritis clinical scores in each group after toonaciliatin K treatment. (d) The expression level of proinflammatory cytokines in each group after toonaciliatin K treatment. Statistical differences in different concentrations were considered significant at the levels of , , or . The statistical differences among vehicle group and control group were considered significant at the levels of .

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