The Anti-Inflammatory Activity of Toonaciliatin K against Adjuvant Arthritis

Figure 4

The antiadjuvant arthritis effect of toonaciliatin K on SD rats. Toonaciliatin K was injected using tail vein at the dosage of 8.3, 16.5, or 33 mg/kg each three days in total of 27 days of administration. The same volume 5% DMSO/saline was injected into vehicle. The IND (20 mg/kg) was administered orally once a day as positive. There was no intervention to control group. After 27 days, rats were sacrificed. (a) HE staining of cartilage; scale bar = 300 μm. (b) The arthritis histological scores regarding HE staining. (c) Safranin O-fast green staining of cartilage; scale bar = 300 μm. (d) The Mankin scores regarding safranin O-fast green staining. (e) The toluidine blue staining of paw sections; scale bar = 300 μm. Statistical differences in different concentrations were considered significant at the levels of or . The statistical differences among vehicle group and control group were considered significant at the levels of .

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