Sensitive Detection of the Natural Killer Cell-Mediated Cytotoxicity of Anti-CD20 Antibodies and Its Impairment by B-Cell Receptor Pathway Inhibitors

Figure 3

Impairment of ADCC against primary CLL cells by kinase inhibitors. The antibody-dependent increase in the percentages of minimal calcein retention was determined in six or seven independent experiments with 3-fold excess of recombinant 26.5 (a) or 1708-LC3E11 (b) effector cells over CLL target cells. Cytotoxicity was compared to controls without antibodies by paired two-tailed t-test. ; ; .

(a)

(b)