Retinoblastoma Binding Protein 5 Correlates with the Progression in Hepatocellular Carcinoma

Table 2

Univariate and multivariate Cox regression analysis of overall survival in 94 HCC patients.

Clinicopathological factor	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Sex, male vs female	0.999 (0.485-2.058)	0.999
Age (years), < 45 vs ≥ 45	1.215 (0.669-2.205)	0.522
HbsAg, positive vs negative	0.738 (0.403-1.351)	0.324
AFP (ng/ml), ≥ 50 vs < 50	1.339 (0.751-2.389)	0.322
Cirrhosis, positive vs negative	1.811 (1.035-3.170)	0.038	1359 (0.705-2.619)	0.360
AJCC stage, III+IV vs I+II	1.793 (1.026-3.132)	0.040	1.326 (0.739-2.379)	0.344
Tumor size (cm), ≥ 5 vs < 5	1.126 (0.644-1.969)	0.676
No. of tumor nodes, multiple vs single	2.845 (1.563-5.180)	0.001	2.417 (1.202-4.860)	0.013
Capsular formation, positive vs negative	0.730 (0.416-1.282)	0.273
Metastasis, positive vs negative	1.539 (0.786-3.014)	0.209
Vein invasion, positive vs negative	1.366 (0.772-2.419)	0.284
RBBP5 expression, high vs low	3.706 (1.880-7.307)	< 0.001	10.631 (3.089-36.592)	< 0.001
Ki-67 expression, high vs low	2.152 (1.139-4.065)	0.018	4.072 (1.227-13.522)	0.022