Effects of Digeda-4 Decoction on the CYP450 Activities in Rats Using a Cocktail Method by HPLC

Figure 1

HPLC chromatograms. ((a) and (d)) Blank plasma. ((b) and (e)) Blank plasma spiked with the cocktail probe drugs and the IS. ((c) and (f)) Plasma sample obtained from a rat after intravenous injection of the cocktail probe drugs spiked with the IS; 1, theophylline; 2, tinidazole; 3, chlorzoxazone; 4, tolbutamide; 5, omeprazole; 6, midazolam.

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