Protein Arginine Methyltransferase 2 Inhibits Angiotensin II-Induced Proliferation and Inflammation in Vascular Smooth Muscle Cells

Figure 2

Ang II reduced PRMT2 expression in a time-dependent and dose-dependent manner. (a-b) Dosage curve of PRMT2 expression when cells were stimulated with different concentrations of Ang II for 24 hours. (a) PRMT2 mRNA level; (b) PRMT2 protein level; P<0.05 versus 0 nM. (c-d) Time curve of PRMT2 expression when cells were stimulated with 100 nM Ang II. (c) PRMT2 mRNA level; (d) PRMT2 protein level; P<0.05 versus 0 h. Ang II represents angiotensin II; VSMCs represent vascular smooth muscle cells; n=3 independent experiments.

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