Increased Autophagy Levels Mediate Cisplatin Resistance in Cisplatin-Resistant Cells While Also Rendering Them Vulnerable to Autophagy Induction

Figure 6

Ddp-resistant cells are more sensitive to rapamycin than ddp-sensitive cells. (a) Relative proliferation of HeLa and HeLa/ddp cells treated with increasing concentrations of rapamycin for 72 h. (b) Relative proliferation of AGS and AGS/ddp cells treated with increasing concentrations of rapamycin for 72 h. The error bars represent the s.d. of triplicate wells of a representative experiment; P<0.05 and P<0.01.

(a)

(b)