MicroRNA-9 Enhanced Cisplatin Sensitivity in Nonsmall Cell Lung Cancer Cells by Regulating Eukaryotic Translation Initiation Factor 5A2

Figure 4

EIF5A2 knockdown enhances NSCLC cell sensitivity to cisplatin. (a) Western blot shows decreased eIF5A2 levels following transfection with eIF5A2 siRNA as compared with negative siRNA. (b) CCK-8 showing decreased cell viability following transfection with eIF5A2 siRNA as compared to negative siRNA. (c) EdU staining determination of cell proliferation following treatment with cisplatin with and without eIF5A2 siRNA transfection. (d) Histogram representation of the EdU-positive cells. < 0.05 and < 0.01 vs. negative siRNA.

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