Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia

Figure 3

(a) Sudan IV staining of whole-mount aortic trees of L/A mice at the indicated ages (weeks), showing the extent of lipid-containing plaque. (b) Percentage of total surface area of aortic trees that contains plaque as a function of age, in L/A mice. (c) Plaque size in aortic sinuses of L/A mice as revealed by morphometric analysis of H&E stained slides. Plaque sizes for each mouse are based on an average of 3 individual equally spaced sections of the aortic sinus. The pixel numbers are converted to μm² with use of a 1 mm x 1 mm calibrator. N = the number of mice used at each time point.

(a)

(b)

(c)