Review Article

Recent Advances in HBV Reactivation Research

Table 1

Three phases of HBV Reactivation.

PHASEFEATUREDIAGNOSTIC MARKERSCOMMENTS

1Increase in HBV Replication PeriodHBV DNA
HBeAg
HBsAg
Rise of > 1 log10 IU/mL
In HBeAg negative
Reverse seroconversion

2Liver Disease
Activity Period
ALT
Jaundice
Symptoms
Rise of > 3 times baseline
Injury
Indicates more serious

3Recovery PeriodHBV DNA
ALT
HBsAg
Drops to the baseline level
Drops to the baseline level
May be negative late