Hepatitis C Virus-Infected Responders and Relapsers to Treatment Show Similar Genetic Profiles of IL28B and IL10 Single Nucleotide Polymorphisms

Table 3

Association between IL28B and IL10 SNPs and relapsers and nonresponders.

Genotype/haplotype	Relapsers	Nonresponders	OR (95% CI)
rs12979860
TT	8 (0.23)	22 (0.36)	Reference
CT	11 (0.31)	28 (0.46)	0.93 (0.32–2.69) ()
CC	16 (0.46)	11 (0.18)	0.25 (0.08–0.76) (p = 0.015)
CC versus CT/TT			0.26 (0.10–0.66) (p = 0.005)
rs8099917
GG	6 (0.17)	18 (0.30)	Reference
GT	7 (0.20)	20 (0.33)	0.95 (0.27–3.37) ()
TT	22 (0.63)	23 (0.38)	0.35 (0.12–1.04) (p = 0.059)
TT versus GT/GG			0.36 (0.15–0.84) ()
rs1800872 (-592)
CC	10 (0.32)	20 (0.36)	Reference
CA	16 (0.52)	22 (0.39)	0.69 (0.25–1.86) ()
AA	5 (0.16)	14 (0.25)	1.4 (0.39–4.99) ()
CA/AA versus CC			0.86 (0.34–2.17) ()
rs1800871 (-819)
CC	9 (0.29)	20 (0.36)	Reference
CT	17 (0.55)	22 (0.39)	0.58 (0.21–1.59) ()
TT	5 (0.16)	14 (0.25)	1.26 (0.35–4.57) ()
CT/TT versus CC			0.74 (0.28–1.90) ()
rs1800896 (-1082)
AA	19 (0.61)	26 (0.46)	Reference
GA	10 (0.32)	24 (0.43)	1.75 (0.68–4.51) ()
GG	2 (0.06)	6 (0.11)	2.19 (0.39–12.07) ()
GA/GG			1.83 (0.74–4.46) ()
rs12979860/rs8099917
T/G	0.18	0.31	Reference
C/G	0.10	0.15	0.84 (0.28–2.54) ()
C/T	0.52	0.26	0.37 (0.18–0.77) (p = 0.009)
T/T	0.21	0.28	0.84 (0.36–1.93) ()

Haplotype frequencies were estimated by maximum likelihood. OR: odds ratio; CI: confidence interval.