Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer’s Disease

Figure 4

The effect of 80 mM of cinnamaldehyde (CM) on climbing ability of 20-day-old Drosophila melanogaster model for Alzheimer’s disease overexpressing MAPT (Tau) and Aβ₄₂ (a) Cinnamaldehyde significantly increased climbing ability of 20-day-old male Alzheimer’s disease flies overexpressing Tau (P = 0.0005, control n = 123, CM n = 120). (b) Cinnamaldehyde showed no significant impact on climbing ability of 20-day-old female Alzheimer disease flies expressing Tau (P > 0.05, control n = 112, CM n = 115). (c) Cinnamaldehyde showed no significant impact on climbing ability of treated 20-day-old male Alzheimer disease flies expressing Aβ₄₂ (P > 0.05, control n = 109, CM n = 121). (d) Cinnamaldehyde showed no significant impact on climbing ability of treated 20-day-old female Alzheimer disease flies expressing Aβ₄₂ (P > 0.05 control n= 112, CM n = 121).

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