Research Article
Significance of Methylation of FBP1 Gene in Non-Small Cell Lung Cancer
Table 1
Association of FBP1 DNA methylation level with clinicopathological factors in the cancer tissue of patients with NSCLC.
| | Factors | Patients, n(%) | FBP1 | P | FBP1 | P | | Median (Mean, 5th-95th) | Low methylation n( % ) | High methylation n( % ) |
| | Sex | | 0.026 | | | 0.009 | | Male | 90(84.11) | 4.86(7.86,5.76-10.00) | | 58(54.21) | 52(48.60) | | | Female | 17(15.89) | 3.75(4.40,1.76-7.03) | | 13(12.15) | 4(3.74) | | | Age(years) | | 0.341 | | | 0.464 | | 65 | 77(71.96) | 4.50(6.70,5.07-8.32) | | 35(32.71) | 42(39.25) | | | 65 | 30(28.04) | 4.13(8.91,3.74-14.10) | | 16(14.95) | 14(13.09) | | | Family History | | 0.752 | | | 0.817 | | no | 87(81.31) | 4.50(6.51,4.93-8.09) | | 41(38.31) | 46(42.99) | | | yes | 20(18.69) | 4.38(10.81,3.57-18.06) | | 10(9.35) | 10(9.35) | | | Smoking | | 0.003 | | | 0.008 | | Never | 22(20.56) | 3.50(3.83,1.97-5.69) | | 16(14.95) | 6(5.61) | | | Ever/Current | 85(79.44) | 5.25(8.22,6.00-10.43) | | 35(32.71) | 50(46.73) | | | Alcohol | | 0.290 | | | 0.164 | | Never | 45(42.06) | 4.25(6.52,3.71-9.34) | | 25(23.36) | 20(18.69) | | | Ever/Current | 62(57.94) | 5.13(7.89,5.44-10.33) | | 26(24.31) | 36(33.64) | | | Histologic type | | 0.160 | | | 0.579 | | Squamous cell carcinoma | 37(34.58) | 4.25(5.01,3.09-6.93) | | 19(17.76) | 18(16.82) | | | Adenocarcinoma | 70(65.42) | 5.00(8.53,5.95-11.11) | | 32(29.91) | 38(35.51) | | | Grade | | 0.073 | | | 0.004 | | high-middle | 58(54.21) | 4.00(7.47,4.53-10.42) | | 35(32.71) | 23(21.50) | | | middle-low | 49(45.79) | 5.50(7.12,5.09-9.15) | | 1614.95() | 33(30.84) | | | Clinical stage | | 0.952 | | | 0.760 | | I - II | 83(77.57) | 4.50(7.23,5.22-9.24) | | 36(33.64) | 38(35.51) | | | III | 24 (22.43) | 4.38(7.60,3.10-12.11) | | 15(14.02) | 18(16.82) | |
|
|
