In Vivo Study on Analgesic, Muscle-Relaxant, Sedative Activity of Extracts of Hypochaeris radicata and In Silico Evaluation of Certain Compounds Present in This Species

Figure 2

3D representation of compound 1 and 2 (gray) interactions (black) with the active sites amino acids (green) of COX1 and COX2 enzyme. (a) Docked pose of compound 1 in the active site of COX1. (b) Docking interactions of compound 2 with the active site key amino acids of COX1. (c) Interactions of compound 1 with COX2 active site residues. (d) Docked pose of compound 2 with the important active site residues of COX2 enzyme.