Yes-Associated Protein 1 as a Novel Prognostic Biomarker for Gastrointestinal Cancer: A Meta-Analysis

Table 1

Main characteristics of all studies included in the meta-analysis.

First author	Year	Country	tumor type	Case number	Follow-up (months)	Detected method	Cut-off value	Multivariate analysis	HRs provided from	Outcome measures	NOS score
Muramatsu	2011	Japan	ESCC	120	1-103	IHC	≥30% of cells stained	yes	Report	OS	7
Yeo	2012	Korea	ESCC	142	over60	IHC	IRS ≥4	yes	Report	OS/DFS	7
Huang	2017	China	GC	120	longest96	IHC	IRS ≥4	yes	Report	OS	9
Hong	2017	Korea	GC	166	0-119	IHC	≥10% of cells stained	no	SC	OS/DFS	8
Hu	2014	China	GC	214	longest65	IHC	IRS ≥4	yes	Report	OS	8
Li	2016	China	GC	161	median34	IHC	IRS >2	yes	Report	OS	8
Song	2012	Korea	GC	223	5-75	IHC	≥50% of cells stained	yes	Report	OS	7
Suh	2015	Korea	GC	116	3-51	IHC	≥10% of cells stained	no	SC	OS/DFS	7
Sun	2017	China	GC	270	107	IHC	≥10% of cells stained	yes	Report	OS	9
Zhang	2017	China	GC	178	80	IHC	IRS ≥3	no	SC	OS	8
Choi	2018	Korea	GC	300	over60	IHC	IRS ≥6	no	SC	OS/DFS	8
Wang	2013	China	CRC	168	1-56	IHC	IRS ≥4	yes	Report	OS	8
Wang	2018	China	CRC	172	longest50	IHC	IRS ≥4	no	SC	OS	7
Wu	2017	China	CRC	85	102 to 2572 days	IHC	H-score >150	yes	Report	OS	7
Kim	2013	Korea	CRC	132	longest125	IHC	IRS ≥7	yes	Report	OS	7
Wang	2013	China	CRC	139	over60	IHC	≥10% of cells stained	yes	Report	OS	8
Ou	2017	China	CRC	90	longest60	IHC	IRS ≥2	no	SC	OS	7
Yang	2018	China	CRC	145	longest125	IHC	IRS ≥2	yes	Report	OS/DFS	8

ESCC: esophageal squamous cell carcinoma; GC: gastric cancer; CRC: colorectal cancer; IHC: immunohistochemistry; IRS: immunoreactivity score; HR: hazard ratio; SC: survival curve; OS: overall survival; DFS: disease free survival; NOS:Newcastle-Ottawa Scale.