Yes-Associated Protein 1 as a Novel Prognostic Biomarker for Gastrointestinal Cancer: A Meta-Analysis

Table 2

Pooled HR for OS of patients with high expression of YAP1 according to subgroup analyses.

Outcome subgroup	No. of patients	No. of studies	Fixed-effects model		Heterogeneity
			HR (95% CI)	P value	I^2 (%)	P
OS	2941	18	1.56(1.29,1.89)	<0.001	55.1	0.003
Tumor type
ESCC	262	2	1.85(1.25,2.73)	0.002	0	0.748
GC	1748	9	1.41(1.02,1.95)	0.037	70	0.001
CRC	931	7	1.92(1.32,2.78)	<0.001	0	0.521
Contry
China	1742	11	1.70(1.26,2.29)	<0.001	67.1	0.001
Korea	1079	6	1.41(1.10,1.80)	0.007	27.7	0.227
Japan	120	1	1.76(1.08,2.88)	0.024	-	-
Case number
<150	1089	9	1.72(1.27,2.33)	<0.001	47	0.057
≥150	1852	9	1.45 (1.13,1.86)	0.003	60	0.009
HR obtained method
Reported	2085	12	1.61(1.24,2.10)	<0.001	64.2	0.001
SC	856	6	1.58(1.25,2.00)	<0.001	21.1	0.275
Analysis type
Multivariate	2085	12	1.61(1.24,2.10)	<0.001	64.2	0.001
Univariate	856	6	1.58(1.25,2.00)	<0.001	21.1	0.275

OS: overall survival; ESCC: esophageal squamous cell carcinoma; GC: gastric cancer; CRC: colorectal cancer; HR: hazard ratio; CI: confidence interval; SC: survival curve.