Influence of Amiodarone and Dronedarone on the Force-Interval Dependence of Rat Myocardium

Table 1

Influence of amiodarone and dronedarone on the contraction-relaxation cycle parameters.

	n	Тmax, %	+dТ/dt, %	-dT/dt, %	t, %	t1, %	t2, %
Before	14	100	100	100	100	100	100
Amiodarone	14	90 ± 3,3	92 ± 2,8	87,1 ± 3,55	102 ± 2,3	102 ± 2,69	104 ± 2,80
Before	8	100	100	100	100	100	100
Dronedarone	8	92 ± 2,90	89 ± 2,69	81 ± 3,01	114 ± 4,69#	106 ± 2,80	116 ± 3,38#

The values of contraction-relaxation cycle parameters after amiodarone or dronedarone treatment were estimated as percentage of the baseline of contraction-relaxation cycle parameters. P < 0.05 versus baseline. # P < 0.05 versus amiodarone.