Combination of Genetic Markers and Age Effectively Facilitates the Identification of People with High Risk of Preeclampsia in the Han Chinese Population

Table 2

Genotype contribution to PE in the Han Chinese population.

SNP^1	Genotype	PE#	CT#	PE_Major	CT_Major	Chi-square	P value	OR	95_Upper	95_Lower
rs2549782^2	TT	42	99	0.27	0.35	2.83	0.09	0.69	1.06	0.45
	TG	88	134
	GG	26	52
rs1695^2	AA	124	211	0.79	0.74	1.79	0.18	1.38	2.20	0.86
	AG	26	67
	GG	6	8
rs2070744	TT	149	284	0.96	0.99	7.26	0.01	0.15	0.73	0.03
	TC	6	2
	CC	1	0
rs1800896	AA	120	248	0.77	0.87	6.29	0.01	0.53	0.87	0.32
	AG	32	32
	GG	3	6
rs1800629^2	GG	139	235	0.89	0.82	3.73	0.05	1.77	3.19	0.99
	GA	16	47
	AA	1	4
rs1799724	CC	92	205	0.59	0.72	7.39	0.01	0.57	0.86	0.38
	CT	61	78
	TT	3	3
rs4762	CC	133	219	0.85	0.77	4.69	0.03	1.77	2.98	1.05
	CT	23	62
	TT	0	5
rs7412^2	CC	129	252	0.83	0.88	2.81	0.09	0.63	1.09	0.36
	CT	27	32
	TT	0	1

The SNP loci showed significant (chi-square test, P < 0.05; indicated in italic) or marginally significant (chi-square test, P ≥ 0.05 and < 0.1) difference in genotype composition between PE and control groups, except rs1695, for which the difference was not (marginally) significant but showed contribution to PE in multilocus interaction analysis and prediction models. ²The 90% confidence interval (upper and lower) for the OR of these SNPs was also calculated: 0.88 and 0.57 for rs2549782, 1.97 and 1.01 for rs1695, 3.01 and 1.22 for rs1800629, and 0.90 and 0.49 for rs7412, respectively. PE# and CT#, the number of patients with PE and controls, respectively; PE_ and CT_major#, the number of patients with PE and controls with the major genotype, respectively; OR, odd ratio; 95%_upper and lower, the 95% upper and lower confidence limits, respectively.