Research Article
Synergistic Effect of Endogenous and Exogenous Aldehydes on Doxorubicin Toxicity in Yeast
Table 2
Formaldehyde and doxorubicin cotreatment enhances the toxicity of doxorubicin.
| | Strain | Formaldehyde (2 mM)
Survival (%) | Doxorubicin (10 μM)
Survival (%) | Expected Additive Effect
Survival (%) | Actual Effect
Survival (%) |
| | msh2 | 32.9 | 22.9 | 7.5 | 6.3 | | siz1 | 65.3 | 54.5 | 35.5 | 23.2 | | Wild type | 77.7 | 61.9 | 48 | 1.89 |
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