Proteomic Analysis of Liver from Human Lipoprotein(a) Transgenic Mice Shows an Oxidative Stress and Lipid Export Response

Figure 2

Representative 2D PAGE images of proteins in the livers of wildtype and Lp(a) mice. Liver protein extracts from 12 wildtype mice (a) and 12 Lp(a) mice (b) were separated by 2D PAGE in triplicate. Comparative analysis of equivalent spots between the averaged gels of the Lp(a) and wildtype mice identified 27 spots with significantly different intensities. Protein spots showing a significant difference in relative abundance (P<0.05) are indicated by their abbreviated protein names and are listed in Table 1.

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(b)