Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis

Table 1

Patient data, modified Rankin Scale (mRS), Barthel Index (BI) and impairment in activities of daily living (ADL) in 18 cases with sIBM.

Case

Sex

Ethnicity

Onset

Evolution

Falls

Dysphagia

WL

Dyspnea

DS

IS

mRS

BI

ADL limitations

2013/2014

2015

2013/2014

2015

2013/2014

2015

1

M

E

40

401

P

P

P

P

P

PLLW

4

4

45

40

moderate

moderate

2

M

E

54

245

P

P

A

P

P

4LW

3

4

85

55

mild

moderate

3

M

E

52

91

A

P

A

P

P

PLLW

3

4

75

55

mild

moderate

4

M

E

65

77

P

P

P

A

P

Dysphagia

2

U

95

U

mild

U

5

M

E

55

89

P

P

P

A

A

PLLW

2

2

95

85

mild

mild

6

F

E

61

63

A

A

A

A

A

PLLW

3

3

75

65

mild

mild

7

M

Af

55

91

P

P

P

A

A

4LW

2

2

100

85

independent

mild

8

F

E

53

125

P

P

P

A

A

PLLW

4

4

75

55

mild

moderate

9

M

E

42

101

A

A

A

A

A

DULW

2

2

90

80

mild

mild

10

F

Af

38

99

A

A

A

P

A

1PULW

3

3

70

60

mild

mild

11

M

E

66

139

P

P

P

A

P

1DLLW

2

2

95

90

mild

mild

12

M

E

60

39

P

A

A

A

A

1DLLW

2

2

95

90

mild

mild

13

F

As

55

126

A

P

P

A

A

4LW

U

2

U

95

U

mild

14

F

E

65

96

P

A

P

A

P

PLLW

2

2

90

85

mild

mild

15

F

E

75

46

P

P

A

A

A

4LW

U

2

U

95

U

mild

16

M

E

73

24

P

P

P

P

A

1DLLW

U

3

U

80

U

mild

17

F

E

64

57

P

P

A

A

A

4LW

U

2

U

85

U

mild

18

M

E

75

60

P

A

A

A

A

PLLW

U

4

U

40

U

moderate

Age of onset of symptoms in years. Time to disease progression in months. Postural instability or falls. WL = weight loss preceding or at onset of the disease. F = female. M = male. As = Asian. E = European. Af = African. DS = depressive symptoms. IS: initial symptom. P = present. A = absent. U = undone. PLLW = proximal lower limbs weakness. 4LW = uncharacterized weakness of the 4 limbs. DULW = distal upper limbs weakness. 1PULW = proximal weakness of one lower limb. 1DLLW: distal weakness of one lower limb.