miR-144-5p Enhances the Radiosensitivity of Non-Small-Cell Lung Cancer Cells via Targeting ATF2

Figure 3

miR-144-5p enhanced the tumor suppression capability of IR in vitro and in vivo. (a) A549 or H460 cells transfected with agomir-144 or agomiR-NC and the parental cells (control) were subjected to 8 Gy radiation, followed by a colony formation assay. Colony formation was suppressed in agomiR-144-5p-transfected A549 cells. versus agomir-NC. (b) Seven days after A549 cell injection in mice (six in each group), agomir-144 or agomir-NC was intratumorally injected into the implanted tumor every 3 days for seven times. Mice were irradiated with 4 Gy once per day for the following 5 days. Tumor volumes were measured every 3 days after injection. (c) Tumors were dissected, and the tumor weights were measured on day 28 after inoculation. versus agomir-NC. versus agomir-NC.

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