BioMed Research International

Research Article

Serum Lipidomics Profiling to Identify Biomarkers for Non-Small Cell Lung Cancer

Table 7

The detection of PCs and PEs as potential biomarkers for distinguishing early-stage NSCLC, LBD, and HC.


Lipid biomarker	NSCLC vs. HC			LBD vs. HC			NSCLC vs. LBD
Lipid biomarker	AUC (95%CI)	Sensitivity (%)	Specificity (%)	AUC (95%CI)	Sensitivity (%)	Specificity (%)	AUC (95%CI)	Sensitivity (%)	Specificity (%)

PE(16:0/16:1)	0.900(0.822-0.978)	80.0	93.3	- -			- -	- -	- -
PE(16:0/18:3)	0.741(0.614-0.868)	66.7	80.0	0.763(0.640-0.887)	70.0	80.0	- -	- -	- -
PE(16:0/18:2)	0.698(0.559-0.837)	60.0	80.0	- -			- -	- -	- -
PE(18:0/16:0)	0.820(0.703-0.937)	70.0	93.3	0.760(0.633-0.887)	66.7	83.3	- -	- -	- -
PE(17:0/18:2)	0.731(0.599-0.863)	56.7	83.3	0.703(0.568-0.839)	70.0	70.0	- -	- -	- -
PE(18:0/17:1)	0.657(0.517-0.796)	66.7	66.7	- -			- -	- -	- -
PE(17:0/18:1)	0.782(0.659-0.906)	73.3	80.0	0.709(0.578-0.840)	46.7	93.3	- -	- -	- -
PE(20:5/16:0)	0.759(0.631-0.887)	76.7	76.7	- -			- -	- -	- -
PE(18:2/18:2)	- -			0.663(0.523-0.804)	53.3	86.7	- -	- -	- -
PE(18:1/18:2)	- -			0.686(0.551-0.820)	63.3	70.0	- -	- -	- -
PE(18:0/18:2)	- -			- -			0.686(0.547-0.824)	43.3	96.7
PE(18:0/18:1)	0.783(0.658-0.908)	73.3	83.3	0.781(0.655-0.907)	80.0	80.0	- -	- -	- -
PE(18:1/20:4)	0.691(0.554-0.828)	60.0	76.7	0.734(0.606-0.862)	70.0	73.3	- -	- -	- -
PE(18:0/20:3)	0.733(0.600-0.867)	50.0	96.7	- -			- -	- -	- -
PC(15:0/18:1)	0.717(0.586-0.848)	60.0	80.0	- -			0.643(0.503-0.784)	36.7	93.3
PC(16:1/20:5)	0.687(0.550-0.823)	53.3	86.7	0.709(0.577-0.841)	86.7	50.0	- -	- -	- -
PC(18:0/20:1)	0.691(0.556-0.826)	66.7	70.0	0.739(0.615-0.863)	63.3	76.7	- -	- -	- -
Panel a	0.963(0.916-1.000)	93.3	93.3	- -			- -	- -	- -
Panel b	- -			0.879(0.789-0.969)	76.7	86.7	- -	- -	- -
Panel c	- -			- -			0.784(0.662-0.906)	70.0	86.7

NSCLC, non-small cell lung cancer; LBD, lung benign disease; HC, healthy controls.
Panel a: PE(16:0/16:1), PE(16:0/18:3), PE(16:0/18:2), PE(18:0/16:0), PE(17:0/18:2), PE(18:0/17:1), PE(17:0/18:1), PE(20:5/16:0), PE(18:0/18:1), PE(18:1/20:4), PE(18:0/20:3), PC(15:0/18:1, PC(16:1/20:5), and PC(18:0/20:1); Panel b: PE(16:0/18:3), PE(18:0/16:0), PE(17:0/18:2), PE(17:0/18:1), PE(18:2/18:2), PE(18:1/18:2), PE(18:0/18:1), PE(18:1/20:4), PC(16:1/20:5), and PC(18:0/20:1); Panel c: PE(18:0/18:2) and PC(15:0/18:1).