Research Article

Computing of Low Shear Stress-Driven Endothelial Gene Network Involved in Early Stages of Atherosclerotic Process

Figure 5

Schematic representation of the enhanced network. (i) Squares represent the genes previously identified in wet lab assessment, (ii) diamonds represent microRNAs, and (iii) hexagons represent transcription factors. The node stroke represents the role of each regulator as follows: angiogenesis (red), apoptosis (dark green), atherogenesis (light green), Inflammatory response (orange), NO synthesis and response (pink), senescence (blue), shear stress regulation (purple), and previously identified genes (light gray).