The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Inflammation in Rheumatic Patients with Arthritis

Figure 3

The association between the risk of arthritis and the expansion of myeloid-derived suppressor cells (MDSCs), as well as their subsets. (a) The pooled risk of arthritis from myeloid-derived suppressor cells (MDSCs) and their subsets. There were 86 patients in arthritis group, including RA, AS, OA, SLE with arthritis, and Gout patients. There were 48 controls, including SLE patients without arthritis, HUA patients, and healthy controls. Both bivariate analysis (a-1) and the binary logistic regression (a-2) were performed. (b) Subgroups analysis with the binary logistic regression for the risk of arthritis was grouped by the different arthritis (b). MDSCs, myeloid-derived suppressor cells; M-MDSCs, monocytic MDSCs; G-MDSCs, granulocytic MDSCs; RA, rheumatoid arthritis; AS, ankylosing spondylitis; OA, osteoarthritis, SLE, systemic lupus erythematosus; OR, odds ratios; 95% CI, 95% confidence interval.

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