Reduced β2GPI Inhibiting Glomerular Mesangial Cells VEGF-NO Axis Uncoupling Induced by High Glucose

Figure 1

The effect of reduced β2GPI on the VEGF-NO axis of HBZY-1 cells treated with high glucose. HBZY-1 cells were exposed to normal glucose, high glucose, or β2GPI. (a) The relative production of NO was qualified by using Nitric Oxide Assay Kit. (b-c) The flow cytometry analysis and mean fluorescence intensity of ROS in HBZY-1 cells exposed to different conditions for the indicated time. (d) VEGF mRNA levels were determined by real-time PCR in six disparate experiments. Data are represented as mean ± SD (n=6). P<0.05 versus NC. ^#P<0.05 versus HG.

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