Screening of Serum Protein Markers for Avascular Osteonecrosis of Femoral Head Differentially Expressed after Treatment with Yuanshi Shengmai Chenggu Tablets

Table 6

Differently enriched pathways were obtained in SANFH versus healthy controls.

Pathway_acc	Pathway_Name	value	Protein in Background	Protein in Diff Exp	Protein list
hsa05010	Alzheimer’s disease	0.015362	7	4	P25705, P02649, P62158, P06576
hsa04970	Salivary secretion	0.032411	5	3	P62158, P04220, P13637,
hsa05016	Huntington’s disease	0.057318	6	3	P25705, P12235, P06576,
hsa05012	Parkinson’s disease	0.057318	6	3	P25705, P12235, P06576,
hsa00190	Oxidative phosphorylation	0.070274	3	2	P25705, P06576,
hsa04261	Adrenergic signaling in cardiomyocytes	0.088785	7	3	P67936, P62158, P13637,
hsa04915	Estrogen signaling pathway	0.125873	4	2	P62158, P14625,
hsa04020	Calcium signaling pathway	0.125873	4	2	P12235, P62158,
hsa04974	Protein digestion and absorption	0.125873	4	2	P13637, P02452,
hsa04260	Cardiac muscle contraction	0.125873	4	2	P67936, P13637,
hsa04961	Endocrine and other; factor-regulated calcium reabsorption	0.162907	1	1	P13637,
hsa04964	Proximal tubule bicarbonate reclamation	0.162907	1	1	P13637,
hsa04960	Aldosterone-regulated sodium reabsorption	0.162907	1	1	P13637,
hsa04070	Phosphatidylinositol signaling system	0.162907	1	1	P62158,
hsa04744	Phototransduction	0.162907	1	1	P62158,
hsa04976	Bile secretion	0.162907	1	1	P13637,
hsa05130	Pathogenic Escherichia coli infection	0.167478	9	3	Q71U36, P63104, P68366,
hsa04918	Thyroid hormone synthesis	0.188181	5	2	P14625, P13637,
hsa04971	Gastric acid secretion	0.188181	5	2	P62158, P13637,
hsa04540	Gap junction	0.253612	6	2	Q71U36, P68366,
hsa04972	Pancreatic secretion	0.299618	2	1	P13637,
hsa04720	Long-term potentiation	0.299618	2	1	P62158,
hsa04911	Insulin secretion	0.299618	2	1	P13637,
hsa05214	Glioma	0.299618	2	1	P62158,
hsa04978	Mineral absorption	0.299618	2	1	P13637,
hsa04973	Carbohydrate digestion and absorption	0.299618	2	1	P13637,
hsa04014	Ras signaling pathway	0.299618	2	1	P62158,
hsa04270	Vascular smooth muscle contraction	0.299618	2	1	P62158,
hsa04910	Insulin signaling pathway	0.299618	2	1	P62158,
hsa05031	Amphetamine addiction	0.299618	2	1	P62158,
hsa04750	Inflammatory mediator regulation of TRP channels	0.299618	2	1	P62158,
hsa04912	GnRH signaling pathway	0.299618	2	1	P62158,
hsa05152	Tuberculosis	0.319543	7	2	P18428, P62158,
hsa05150	Staphylococcus aureus infection	0.334256	18	4	P00751, P0C0L4, P13645, P02747
hsa04120	Ubiquitin mediated proteolysis	0.357215	13	3	P01742, P01781, P01743,
hsa04114	Oocyte meiosis	0.3841	8	2	P63104, P62158,
hsa04919	Thyroid hormone signaling pathway	0.41429	3	1	P13637,
hsa04916	Melanogenesis	0.41429	3	1	P62158,
hsa04064	NF-kappa B signaling pathway	0.41429	3	1	P18428,
hsa04728	Dopaminergic synapse	0.41429	3	1	P62158,
hsa04621	NOD-like receptor signaling pathway	0.41429	3	1	P14625,
hsa05215	Prostate cancer	0.41429	3	1	P14625,
hsa04740	Olfactory transduction	0.41429	3	1	P62158,
hsa04620	Toll-like receptor signaling pathway	0.41429	3	1	P18428,
hsa04713	Circadian entrainment	0.41429	3	1	P62158,
hsa03320	PPAR signaling pathway	0.445992	9	2	P08519, Q6Q788,
hsa05133	Pertussis	0.45325	15	3	P0C0L4, P62158, P02747,

Note. Italic font indicated the candidate protein.