Inflammatory Cellular Response to Mechanical Ventilation in Elastase-Induced Experimental Emphysema: Role of Preexisting Alveolar Macrophages Infiltration

Figure 3

Evolution of dynamic compliance, calculated using the single frequency forced oscillation technique, during two hours of mechanical ventilation in Saline and Elastase mice, at D14 (a) and D21 (b) of tracheal instillation. Values are expressed as median ± interquartile range. n = 6 animals/group at D14, and 13 animals/group at D21. ^£, , , and denote p value <0.10 (marginally significant), <0.05, <0.01, and <0.001, respectively, for the Mann-Whitney pairwise comparisons (following Kruskal-Wallis test), Elastase MV versus Saline MV. Definition of abbreviations: MV: mechanical ventilation; H0: at ventilator connection; H0’: after volume history standardization (recruitment maneuver); H1: after one hour of MV; H2: at the end of MV.

(a) D14

(b) D21