Gene Expression Patterns Analysis in the Supraspinatus Muscle after a Rotator Cuff Tear in a Mouse Model

Table 2

The top 10 up- and downregulated genes after rotator cuff tear (at weeks 1 and 4).

(a)

Gene symbol	Genbank accession	Fold change	Gene name
Upregulated
Krt18	NM_010664	217.799	keratin 18
Sirpb1b	NM_001173460	150.129	signal-regulatory protein beta 1B
Cd300lf	NM_001169153	128.186	CD300 antigen like family member F
Ms4a4c	NM_029499	122.342	membrane-spanning 4-domains, subfamily A, member 4C
Plekhh1	NM_181073	119.491	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
Cd5l	NM_009690	104.575	CD5 antigen-like
Krt8	AK166854	104.209	keratin 8
Myh8	AK081482	95.091	myosin, heavy polypeptide 8, skeletal muscle, perinatal
LOC102642410	XM_006544504	94.351	tyrosine-protein phosphatase non-receptor type substrate 1-like
Myh3	NM_001099635	92.621	myosin, heavy polypeptide 3, skeletal muscle, embryonic
Downregulated
Pitx1	NM_011097	0.025	paired-like homeodomain transcription factor 1
Adam28	NM_183366	0.025	a disintegrin and metallopeptidase domain 28
Rnf180	NM_027934	0.027	ring finger protein 180
Gm5860	NR_040659	0.029	predicted gene 5860
H2-M9	NM_008205	0.03	histocompatibility 2, M region locus 9
Smco1	NM_183283	0.03	single-pass membrane protein with coiled-coil domains 1
AU042410	BB209673	0.031	expressed sequence AU042410
Kcnc1	NM_001112739	0.031	potassium voltage gated channel, Shaw-related subfamily, member 1
8430426J06Rik	NR_077229	0.032	RIKEN cDNA 8430426J06 gene
Gm10822	AK144860	0.033	predicted gene 10822

(b)

Gene symbol	Genbank accession	Fold change	Gene name
Upregulated
Gm7325	NM_001177470	45.121	predicted gene 7325
Plekhh1	NM_181073	42.051	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
Ces2b	NM_198171	28.227	carboxylesterase 2B
Ces2c	NM_145603	25.457	carboxylesterase 2C
Sln	NM_025540	24.155	sarcolipin
Krt18	NM_010664	22.114	keratin 18
Myh3	NM_001099635	17.984	myosin, heavy polypeptide 3, skeletal muscle, embryonic
Krt8	AK166854	16.550	keratin 8
Zfp735	NM_001126489	15.836	zinc finger protein 735
Epha1	NM_023580	15.534	Eph receptor A1
Downregulated
Dok6	NM_001039173	0.063	docking protein 6
Snhg11	NM_175692	0.072	small nucleolar RNA host gene 11
Olfr981	NM_146286	0.087	olfactory receptor 981
Pitx1	NM_011097	0.087	paired-like homeodomain transcription factor 1
Gm12	NM_001195544	0.093	predicted gene 12
Olfr586	NM_147111	0.098	olfactory receptor 586
Samd11	XR_881429	0.101	sterile alpha motif domain containing 11
Dnase1	NM_010061	0.111	deoxyribonuclease I
1190003K10Rik	NM_001195435	0.114	RIKEN cDNA 1190003K10 gene
Gpr176	NM_201367	0.117	G protein-coupled receptor 176