Gene Expression Patterns Analysis in the Supraspinatus Muscle after a Rotator Cuff Tear in a Mouse Model

Table 3

Gene expression patterns after rotator cuff tear in the aging category ((a) week 1 after tear; (b) week 4 after tear).

(a)

Gene symbol	Genbank accession	Fold change	Gene name
Upregulated
Igfbp2	NM_008342	55.685	insulin-like growth factor binding protein 2
Arg1	NM_007482	54.973	arginase, liver
Cdk1	NM_007659	34.242	cyclin-dependent kinase 1
Cdkn2a	NM_009877	30.112	cyclin-dependent kinase inhibitor 2A
Aldh3a1	NM_007436	19.548	aldehyde dehydrogenase family 3, subfamily A1
Ddc	NM_001190448	17.423	dopa decarboxylase
Ccl2	NM_011333	16.814	chemokine (C-C motif) ligand 2
Inpp5d	NM_010566	15.961	inositol polyphosphate-5-phosphatase D
Mpo	NM_010824	14.836	myeloperoxidase
Rad54l	NM_009015	13.26	RAD54 like (S. cerevisiae)
Downregulated
Tfcp2l1	NM_023755	0.125	transcription factor CP2-like 1
Nat1	NM_008673	0.146	N-acetyl transferase 1
Ppargc1a	NM_008904	0.153	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Atp8a2	NM_015803	0.157	ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Pde4d	NM_011056	0.183	phosphodiesterase 4D, cAMP specific
Endog	NM_007931	0.195	endonuclease G
Cyp1a1	NM_009992	0.199	cytochrome P450, family 1, subfamily a, polypeptide 1
Kl	NM_013823	0.2	klotho
Cryab	NM_001289782	0.21	crystallin, alpha B
P2ry1	NM_008772	0.216	purinergic receptor P2Y, G-protein coupled 1

(b)

Gene symbol	Genbank accession	Fold change	Gene name
Upregulated
Slc1a2	NM_001077514	10.851	solute carrier family 1 (glial high affinity glutamate transporter), member 2
Krtap4-16	NM_001013823	9.991	keratin associated protein 4-16
Ghrhr	NM_001003685	9.285	growth hormone releasing hormone receptor
Ddc	NM_001190448	8.068	dopa decarboxylase
Aldh3a1	NM_007436	7.897	aldehyde dehydrogenase family 3, subfamily A1
Cdkn2a	NM_009877	6.885	cyclin-dependent kinase inhibitor 2A
Igfbp2	NM_008342	5.164	insulin-like growth factor binding protein 2
Retn	NM_001204959	3.729	resistin
Adra1a	NM_013461	3.523	adrenergic receptor, alpha 1a
Cnr1	NM_007726	3.51	cannabinoid receptor 1 (brain)
Downregulated
Il10	NM_010548	0.195	interleukin 10
Cdk1	NM_007659	0.227	cyclin-dependent kinase 1
Glrx2	NM_001038592	0.325	glutaredoxin 2 (thioltransferase)
Tfcp2l1	NM_023755	0.391	transcription factor CP2-like 1
Fos	NM_010234	0.438	FBJ osteosarcoma oncogene
Atp8a2	NM_015803	0.459	ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Hmga1	NM_001166546	0.462	high mobility group AT-hook 1
Bcl2	NM_177410	0.464	B-cell leukemia/lymphoma 2
Srf	NM_020493	0.482	serum response factor
Arntl	NM_007489	0.519	aryl hydrocarbon receptor nuclear translocator-like