Gene Expression Patterns Analysis in the Supraspinatus Muscle after a Rotator Cuff Tear in a Mouse Model

Table 4

Gene expression patterns in the apoptosis category after rotator cuff tear ((a) week 1 after tear; (b) week 4 after tear).

(a)

Gene symbol	Genbank accession	Fold change	Gene name
Upregulated
Krt18	NM_010664	217.799	keratin 18
Cd5l	NM_009690	104.575	CD5 antigen-like
Krt8	AK166854	104.209	keratin 8
Serpina3g	NM_009251	85.473	serine (or cysteine) peptidase inhibitor, clade A, member 3G
Melk	NM_010790	72.784	maternal embryonic leucine zipper kinase
Birc5	NM_009689	55.603	baculoviral IAP repeat-containing 5
Gpr65	NM_008152	54.323	G-protein coupled receptor 65
Gzma	NM_010370	52.943	granzyme A
Top2a	NM_011623	44.234	topoisomerase (DNA) II alpha
Bcl2a1d	NM_007536	43.608	B-cell leukemia/lymphoma 2-related protein A1d
Downregulated
Dnase1	NM_010061	0.051	deoxyribonuclease I
Casp14	NM_009809	0.099	caspase 14
Robo2	BC055333	0.104	roundabout homolog 2 (Drosophila)
Camk2a	NM_009792	0.107	calcium/calmodulin-dependent protein kinase II alpha
Il24	NM_053095	0.112	interleukin 24
Chac1	NM_026929	0.119	ChaC, cation transport regulator 1
Nr4a1	NM_010444	0.122	nuclear receptor subfamily 4, group A, member 1
Mtfp1	NM_026443	0.124	mitochondrial fission process 1
Rps6ka2	NM_011299	0.156	ribosomal protein S6 kinase, polypeptide 2
Casr	NM_013803	0.158	calcium-sensing receptor

(b)

Gene symbol	Genbank accession	Fold change	Gene name
Upregulated
Krt18	NM_010664	22.114	keratin 18
Krt8	AK166854	16.55	keratin 8
Bcl2l14	NM_025778	14.994	BCL2-like 14 (apoptosis facilitator)
Tox3	NM_172913	10.794	TOX high mobility group box family member 3
Fasl	NM_010177	10.487	Fas ligand (TNF superfamily, member 6)
Pak7	NM_172858	9.86	p21 protein (Cdc42/Rac)-activated kinase 7
Fgf21	NM_020013	7.87	fibroblast growth factor 21
Avp	NM_009732	7.557	arginine vasopressin
Nlrc4	NM_001033367	7.471	NLR family, CARD domain containing 4
Cdkn2a	NM_009877	6.885	cyclin-dependent kinase inhibitor 2A
Downregulated
Dnase1	NM_010061	0.111	deoxyribonuclease I
Cd27	NM_001033126	0.117	CD27 antigen
Fgf8	NM_010205	0.162	fibroblast growth factor 8
AY074887	NM_145229	0.168	cDNA sequence AY074887
Tnf	NM_013693	0.205	tumor necrosis factor
Naip1	NM_008670	0.217	NLR family, apoptosis inhibitory protein 1
Cdk1	NM_007659	0.227	cyclin-dependent kinase 1
Epha7	NM_010141	0.239	Eph receptor A7
Tiam1	NM_009384	0.253	T-cell lymphoma invasion and metastasis 1
Bub1	NM_009772	0.284	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)