Liposomal Incorporation to Improve Dissolution and Stability of Rosmarinic Acid and Carvacrol Extracted from Oregano (O. onites L.)

Table 4

LE1 storage stability data under different conditions (4°C and 25°C).

Conditions	Time (Mon)	Mean Size (nm)	Zeta potential (mV)	PDI	EE RA	EE CA
4°C±0.5°C/60  ±  5  RH^1	Initial	234.3±35.56	-30.9 ± 9.12	0.35±0.02	90.12±0.13	65.5±1.2
	1	236.9±12.5	-31.0±1.2	0.34±0.03	90±1.2	65.5±3.4
	3	234.1±23.12	-33.8±4.6	0.33±0.02	89.9±2.3	65.4±1.4
	6	240.1± 23.5	-32.78±3.9	0.33±0.01	89.9±1.3	65.3±0.3
25°C±2°C/60  ± 5  RH^1	Initial	234.56±12.5	-32.6 ± 9.12	0.32±0.01	90.15±0.45	66.2±1.6
	1	235.01±16.7	-33.8±7.45	0.31±0.01	90.1±0.34	66±1.9
	3	236.7±12.6	-32.0±2.4	0.3±0.02	89.1±1.2	65.9±2.4
	6	239.98±9.4	-33.9±2.3	0.32±0.01	89.9±1.2	65.8±3.5
	9	239.99±8.2	-33.1±4.7	0.31±0.02	87.7±3.4	64.9±2.4
	12	240.0±2.4	-33.0±5.6	0.33±0.01	87.9±5.6	64.7±5.6

All values are mean values of triplicate samples of each time point.
: relative humidity.